/anatomy/channels_item/4 en /anatomy/node/1863 <p>This summer, department members participated in our inaugural Scientific Image Contest: "Life Magnified: An Anatomy and Cell Biology Exploration."聽</p> Thu, 22 Aug 2024 14:22:09 +0000 91社区 /anatomy/node/1858 <p>Congratulations to Prof. Venne for this accomplishment!聽</p> Tue, 11 Jun 2024 17:33:13 +0000 91社区 /anatomy/node/1857 Thu, 06 Jun 2024 14:03:27 +0000 91社区 /anatomy/node/1856 <p>Congratulations to Prof. Charles E. Smith on receiving an honorary doctorate from聽L'Universit茅 Laval!</p> <p>Pictured is Prof. Smith holding his award with the Secretary General (right side, Monique Richer), the Dean of the Dental School (Petros Papagerakis, left side), and the Rector (in red gown, Sophie D鈥橝mours) of Universit茅 Laval.</p> Wed, 05 Jun 2024 18:25:24 +0000 91社区 /anatomy/node/1855 <p>Two faculty members of the Department of Anatomy and Cell Biology joined forces to bridge the field of cryo-electron microscopy (Mike Strauss) and extracellular matrix cell biology (Dieter Reinhardt). This interdisciplinary team also spanned faculties across 91社区, as Michael Wozny (Faculty of Medicine and Health Sciences) and Valentin Nelea (Faculty of Dental Medicine and Oral Health Sciences) spearheaded the experimental approaches together with other team members and a visiting scholar.</p> Thu, 30 May 2024 14:36:28 +0000 91社区 /anatomy/node/1854 Wed, 22 May 2024 20:03:34 +0000 91社区 /anatomy/node/1852 <p>A useful tool in protein research comes from the collaborative efforts of two bright 91社区 undergraduates, Jerry Gao and Maxwell Tong. Under the supervision of postdoctoral fellow Thibault Legal and Associate Professor Khanh Huy Bui, Jerry and Max developed the DomainFit program for the identification of protein domains in cryo-electron microscopy (cryo-EM) maps at intermediate resolutions.</p> Wed, 15 May 2024 17:17:24 +0000 91社区 /anatomy/node/1848 <h2>Effect of 伪-tubulin acetylation on the doublet microtubule structure.</h2> Wed, 17 Apr 2024 16:40:44 +0000 91社区 /anatomy/node/1844 <p>Cell division is a fundamental process for growth and repair in our bodies. It relies on the beautiful and complex machinery of the mitotic spindle to ensure the accurate distribution of genetic material. The spindle is made up of tiny structures called microtubules, which act like molecular cables to move chromosomes to the right places. When these microtubules don't work properly, cells can end up with the wrong number of chromosomes, a condition known as aneuploidy, which is linked to cancer.</p> Wed, 28 Feb 2024 20:51:42 +0000 91社区 /anatomy/node/1833 <p><strong>Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption</strong></p> Tue, 07 Nov 2023 16:14:33 +0000 91社区 /anatomy/node/1832 <p>CEP104/FAP256 and associated cap complex maintain stability of the ciliary tip</p> Mon, 06 Nov 2023 19:58:43 +0000 91社区 /anatomy/node/1831 <p>91社区鈥檚 Body Donor Program plays crucial role in health sciences education</p> <p>Overall, donors have an impact on the education of more than a thousand students every year.</p> Thu, 02 Nov 2023 20:12:44 +0000 91社区 /anatomy/node/1828 <p>Neha Dinesh, PhD student in the Reinhardt lab, won the Iozzo Trainee Award at the combined conference of the American Society for Matrix Biology, the American Society for Investigative Pathology, and the Histochemical Society held in Salt Lake City, Utah from Oct 22-25, 2023. The title of her contribution was 鈥�<i>Fibronectin-Mediated Physiological and Pathological Mechanisms in Skeletal Development</i>鈥�. The Iozzo Trainee Award is given to a graduate student who has demonstrated outstanding contributions to the field of matrix biology and a continuing commitment to matrix biology research.</p> Thu, 26 Oct 2023 15:32:46 +0000 91社区 /anatomy/node/1818 <p><strong>Effects of Heparan sulfate acetyl-CoA: Alpha-glucosaminide N-acetyltransferase (HGSNAT) inactivation on the structure and function of epithelial and immune cells of the testis and epididymis and sperm parameters in adult mice.</strong></p> Fri, 29 Sep 2023 14:34:52 +0000 91社区 /anatomy/node/1812 <p><strong>Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism.</strong></p> Mon, 18 Sep 2023 19:45:54 +0000 91社区 /anatomy/node/1804 <p>This past July 17-21st, the Department of Anatomy and Cell Biology hosted the Fascia Summer School in collaboration with the University of Padua, Italy.聽</p> <p>The event featured didactic lectures on the most recent advances in fascia, dissection labs conducted by our lead anatomists, Carla Stecco and Gabriel Venne, and hands-on workshops to expose participants to the different fields of practice and research on fascia.</p> <p>Thank you to Prof. Venne and the Division of Anatomical Sciences for their work in ensuring the success of this event!</p> Mon, 31 Jul 2023 20:29:19 +0000 91社区 /anatomy/node/1798 <p>The department would like to congratulate FEMR staff Kelly Sears and Jeannie Mui on receiving the Technologist Award from the Microscopy Society of Canada for 2019 and 2021, respectively.</p> <p>The Technologist Award recognizes those who have made significant contributions to the advancement of microscopy research or training. Congratulations to Kelly and Jeannie!</p> <p>聽</p> <p>聽</p> Mon, 19 Jun 2023 20:32:04 +0000 91社区 /anatomy/node/1790 <p>Sustainability in research: If you want to green your lab, start with the freezer</p> <p>Cell biology researcher Dieter Reinhardt explains why his lab is cool with turning up the temperature of their freezers</p> <p>By聽<strong>Maya Willard-Stepan,</strong>聽Communications Intern, 91社区 Office of Sustainability</p> <p>APRIL 6, 2023</p> <p>聽聽聽</p> Fri, 21 Apr 2023 15:27:30 +0000 91社区 /anatomy/node/1789 Wed, 12 Apr 2023 16:57:59 +0000 91社区 /anatomy/node/1666 Wed, 08 Jun 2022 15:44:31 +0000 91社区 /anatomy/node/1661 <p>Galenvs Sciences Inc. and the FEMR at 91社区 Announce Partnership聽Agreement</p> <p>MARCH 10, 2022</p> <p><strong>聽 Published on Health e-News - 91社区聽</strong></p> <p><img alt="Electron Microscope Facility" src="https://healthenews.mcgill.ca/wp-content/uploads/2022/03/2022-03-11_FEMR_1080x566.jpg" style="height:566px" /></p> Fri, 18 Mar 2022 14:26:58 +0000 91社区 /anatomy/node/1653 <p>聽</p> Celebrating a career dedicated to science and聽teaching - Published on Health e-News <p>By聽Jason Clement</p> <p>FEBRUARY 24, 2022</p> <p>聽聽聽</p> Fri, 25 Feb 2022 16:31:56 +0000 91社区 /anatomy/node/1639 <p style="text-align:center"><img alt="Picture of Mikaela Stiver" src="/anatomy/files/anatomy/styles/wysiwyg_medium/public/styver.jpg?itok=MCWIN4dd" /></p> Wed, 26 Jan 2022 15:36:23 +0000 91社区 /anatomy/node/1630 <table> <tr> <td> <p>There are collectible trading card games for almost everything these days. Besides Pok茅mon, there are, of course, cards for athletes, celebrities, TV and movie characters, and musical instruments, just to name a few.</p> <p>聽</p></td></tr></table> Tue, 07 Dec 2021 14:23:42 +0000 91社区 /anatomy/node/1609 <p>Glucose homeostasis and growth essentially depend on the hormone insulin engaging its receptor. Despite biochemical and structural advances, a fundamental contradiction has persisted in the current understanding of insulin ligand鈥搑eceptor interactions. While biochemistry predicts two distinct insulin binding sites, 1 and 2, recent structural analyses have resolved only site 1. Using a combined approach of cryo-EM and atomistic molecular dynamics simulation, we present the structure of the entire dimeric insulin receptor ectodomain saturated with four insulin molecules.</p> Mon, 17 Feb 2020 19:51:22 +0000 91社区 /anatomy/node/1597 <p>Dr. Charles E. Smith聽continues long-standing collaborative investigations with Dr. James Simmer and Dr. Jan Hu from the University of Michigan about how ameloblasts coordinate their activities to produce the protective enamel covering of teeth as well as flawed responses that occur from these cells when matrix formation/signaling is disrupted by genetic alterations.</p> <p>Below is a list of recent publications:</p> Thu, 28 Nov 2019 19:04:52 +0000 91社区 /anatomy/node/1594 <p><u>Peter S. McPherson</u></p> <h3>Opinion: Scientists Need to Demand Better Antibody Validation</h3> <p>My lab has developed a protocol to easily assess the specificity of antibodies鈥攁nd hopefully stem some of the reproducibility crisis.</p> <p>聽</p> <p><strong><a href="/neuro/article/research/opinion-scientists-need-demand-better-antibody-validation" target="_blank">Click here to read the full article.</a></strong></p> Wed, 30 Oct 2019 17:30:11 +0000 91社区 /anatomy/node/1593 <p>Reinhardt lab receives funding from the prestigious Marfan Foundation (USA) to explore the connection between diet and disease development in Marfan syndrome. Congratulations!</p> Tue, 08 Oct 2019 15:15:04 +0000 91社区 /anatomy/node/1590 <p><strong>TITLE</strong>:聽Augmentation of cell numbers and function in the immune system by <i>in vivo</i> administration of North American (NA) ginseng (<i>Panax Quinquefolium</i>): Assessment in normal and cancer-bearing infant, juvenile, adult and elderly mice</p> Mon, 07 Oct 2019 17:26:06 +0000 91社区 /anatomy/node/1588 <p><b><u>Title</u>:</b> Fibulin-4 exerts a dual role in LTBP-4L鈥搈ediated matrix assembly and function</p> Mon, 30 Sep 2019 13:31:11 +0000 91社区 /anatomy/node/1580 <p>Amal Seffouh, a Postdoctoral Fellow in the Ortega lab, publishes her most recent work about the role of RbgA in the maturation of the 50S ribosomal subunit.</p> <p>聽</p> <p><a href="https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz770/5563945?guestAccessKey=5b4e9773-efcd-4446-bb03-80e7008d5333" target="_blank">Click here to read the paper.</a></p> <p>聽</p> Mon, 09 Sep 2019 18:32:13 +0000 91社区 /anatomy/node/1577 <p>Congratulations to Dr. Marc McKee for receiving the ASBMR 2019 Adele L. Boskey Award! The Adele L Boskey Esteemed Award for Bone and Mineral Research recognizes an American Society for Bone and Mineral Research member for outstanding and major scientific contributions, leadership and mentorship in the area of bone and mineral research especially in the areas of mechanisms of mineralization, bone mineral, bone quality, and mechanobiology.<p></p></p> <p><p> </p></p> Tue, 13 Aug 2019 18:26:22 +0000 91社区 /anatomy/node/1573 <p>Aida Razi鈥檚 last PhD thesis chapter now published online in the Nucleic Acids Research journal. This publication features the first cryo-EM structures obtained by the Ortega lab in the Titan Krios microscope at FEMR-91社区.</p> <p>聽</p> <p>Read the paper at <a href="https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz571/5527280?searchresult=1">https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz571/5527280?searchresult=1</a></p> Thu, 04 Jul 2019 15:58:37 +0000 91社区 /anatomy/node/1572 <p>Dr. Kelly Sears, Research Manager at the Facility for Electron Microscopy Research (FEMR) is awarded the Microscopical Society of Canada Technologist Award 2019. This award recognizes his passion and dedication to FEMR research mission. Congratulations!<p></p></p> <p>聽</p> Wed, 15 May 2019 17:02:17 +0000 91社区 /anatomy/node/1568 <p>The telomerase holoenzyme responsible for maintaining telomeres in vertebrates requires many components in vivo, including dyskerin. Dyskerin binds and regulates the accumulation of the human telomerase RNA, hTR, as well as other non-coding RNAs that share the conserved H<i>/</i>ACA box motif. The precise mechanism by which dyskerin controls hTR levels is unknown, but is evidenced by defective hTR accumulation caused by substitutions in dyskerin, that are observed in the X-linked telomere biology disorder dyskeratosis congenita (X-DC).</p> Tue, 23 Apr 2019 13:40:38 +0000 91社区 /anatomy/node/1564 <p>Reinhardt lab receives 5-year CIHR grant to investigate extracellular matrix-mediated regulation of microRNAs in health and disease. Congratulations!</p> Thu, 24 Jan 2019 16:21:34 +0000 91社区 /anatomy/node/1561 <p>Fibrillins are the major components of microfibrils in the extracellular matrix of elastic and non-elastic tissues. Fibrillin-1 contains one evolutionarily conserved RGD sequence that mediates cell鈥搈atrix interactions through cell-surface integrins. The Reinhardt lab presents a novel paradigm how extracellular fibrillin-1 controls cellular function through integrin-mediated microRNA regulation.</p> Tue, 08 Jan 2019 19:12:37 +0000 91社区 /anatomy/node/1557 <p>One of the tightest bottlenecks in vascular tissue engineering is the lack of strength and elasticity of engineered vascular wall models caused by limited elastic fiber deposition. In this study, collagen gel-based scaffolds were cellularised with vascular smooth muscle cells (SMCs) and supplemented with human plasma fibronectin (FN), a known master organizer of several extracellular matrix (ECM) fiber systems.</p> Thu, 09 Aug 2018 13:30:49 +0000 91社区 /anatomy/node/1556 <p>Fibronectin is a protein that exists in vertebrates in two distinct forms: one present in the blood and the other in blood vessel walls. In mammals, fibronectin is important for the development of blood vessels before birth, but whether it is continuously required for blood vessel homeostasis from birth to adulthood is unknown. We present important results from three genetically modified mouse models, which show that at least one form of fibronectin is required for the proper function and integrity of blood vessels during this period.</p> Wed, 08 Aug 2018 17:28:09 +0000 91社区 /anatomy/node/1555 <p><a href="https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31046-5">C24 Sphingolipids Govern the Transbilayer Asymmetry of Cholesterol and Lateral Organization of Model and Live-Cell Plasma Membranes</a></p> <p>聽</p> Wed, 25 Jul 2018 13:55:49 +0000 91社区 /anatomy/node/1535 <p>How is it that fertilized chicken eggs manage to resist fracture from the outside, while at the same time, are weak enough to break from the inside during chick hatching? It鈥檚 all in the eggshell鈥檚 nanostructure, according to a new study led by 91社区 scientists.</p> <p>The findings, reported today in Science Advances, could have important implications for food safety in the agro-industry.</p> Wed, 04 Apr 2018 14:10:52 +0000 91社区 /anatomy/node/1371 <p>A new, state-of-the-art gross anatomy laboratory is in the works!聽 Learn more about the Strathcona Building and our plans for a cutting-edge anatomy teaching laboratory <a href="/anatomy/files/anatomy/anatomy_lab_presentation_document_0.pdf">HERE</a>!</p> Fri, 09 Mar 2018 17:01:37 +0000 91社区 /anatomy/node/1370 <p>Congratulations to Assistant Professor Dr. Huy Bui, who has been named a 2017 CIFAR Azrieli Global Scholar!</p> Fri, 09 Mar 2018 16:57:14 +0000 91社区 /anatomy/node/1369 <p>Unique collaboration of Dr. Dieter Reinhardt with geneticist Dr. Philippe Campeau at the Sainte-Justine Research Center leads to the identification of a new gene causing scoliosis and bone malformations, published in the American Journal of Human Genetics.</p> Fri, 09 Mar 2018 16:55:03 +0000 91社区 /anatomy/node/1368 <p><a href="http://www.youtube.com/watch?v=WCpUiv7Ic2E&amp;feature=youtu.be">Watch the video here!</a></p> Fri, 09 Mar 2018 16:51:46 +0000 91社区 /anatomy/node/1367 <p>Congratulations to Dr. Carlos Morales, who has been awarded the prestigious Domingo Sarmiento Distinction by the Senate of Argentina for his contributions to medical science.</p> Fri, 09 Mar 2018 16:48:23 +0000 91社区 /anatomy/node/1366 <p>Collaboration between departmental members Drs. D. Reinhardt and P. Campeau has received new 5-year funding from the Canadian Institutes of Health Research for the grant entitled 鈥淩ole of fibronectin mutations in spondylometaphyseal dysplasia and idiopathic scoliosis鈥� in the amount of $680,850. Congratulations!</p> <p>聽</p> <p>聽</p> Fri, 09 Mar 2018 16:42:05 +0000 91社区