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Dr. Benoit Chabot
Professor
Canada Research Chair in Functional Genomics
D茅partement de microbiologie et d'infectiologie
Facult茅 de m茅decine et des sciences de la sant茅
Universit茅 de Sherbrooke

The recent recognition that alternative splicing diversifies the protein output of almost all human genes was an occasion to note how little we understand molecular strategies used by a cell to control splicing decisions. Likewise, we need to devote more efforts at documenting the full repertoire and understanding the functional contribution of splicing variants expressed in specific cells and in various diseases including cancer. By studying ovarian and breast cancer-specific splicing we have identified complex splicing signatures associated with these cancers, and have discovered that the Fox2 protein is regulating a large subset of these cancer-relevant splicing events.