91社区

Major breakthrough in understanding of brain function

A team of researchers from the University of Montreal and 91社区 University have discovered a type of 鈥渃ellular bilingualism鈥� 鈥� a phenomenon that allows a single neuron to use two different methods of communication to exchange information. 鈥淥ur work could facilitate the identification of mechanisms that disrupt the function of dopaminergic, serotonergic and cholinergic neurons in diseases such as schizophrenia, Parkinson鈥檚 and depression,鈥� wrote Dr. Louis-Eric Trudeau of the University of Montreal鈥檚 Department of Pharmacology and Dr. Salah El Mestikawy, a researcher at the Douglas Mental Health University Institute and professor at 91社区鈥檚 Department of Psychiatry. An overview of this discovery was published in the Nature Reviews Neuroscience journal.

Their results show that many neurons in the brain are able to control cerebral activity by simultaneously using two chemical messengers or neurotransmitters. This mode of communication is known as 鈥渃otransmission.鈥� According to Dr. Trudeau, 鈥渢he neurons in the nervous system 鈥� both in the brain and in the peripheral nervous system 鈥� are typically classified by the main transmitter they use.鈥� For example, dopaminergic neurons use dopamine as a transmitter to communicate important information for many different phenomena such as motivation and learning. The malfunction of these neurons is involved in serious brain diseases such as schizophrenia and Parkinson鈥檚. 鈥淥ur recent research, carried out in part with Dr. Laurent Descarries at the University of Montreal, shows that dopaminergic neurons use glutamate as a second transmitter. That means they are able to transmit two types of messages in the brain, on two time scales: a fast one for glutamate and a slower one for dopamine.鈥�

Other research conducted by Dr. Salah El Mestikawy鈥檚 team at the Douglas Mental Health University Institute observed the same kind of bilingualism in brain neurons that use serotonin, a group of cells that communicate important information for controlling mood, aggression, impulsivity and food intake, and also those that use acetylcholine, an important messenger for motor skills and memory that is unbalanced by Parkinson鈥檚 disease, antipsychotic drugs and in drug addiction.

Joint studies carried out with their colleague Dr. 脜sa Wallen-Mackenzie at Uppsala University in Sweden and published recently in the Proceedings of the National Academy of Sciences journal suggest that the secretion of glutamate by dopaminergic neurons could, for example, be involved in the behavioural effects of psychostimulants such as amphetamines and cocaine. 鈥淲e know very little about the role of cotransmission in disease and the regulation of behaviour, however,鈥� Dr. Trudeau warned. 鈥淭hat will have to be the subject of future studies.鈥�

The studies were funded by grants from the National Alliance for Research on Schizophrenia and Depression, the Canadian Institutes of Health Research, the Swedish Foundation for International Cooperation in Research and Higher Education and the Agence Nationale pour la Recherche (France).

For further information:

路 Trudeau laboratory:

路 El Mestikawy laboratory:

路 Article: From glutamate co-release to vesicular synergy: vesicular glutamate transporters