听
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听 Andrew Bateman, Ph.D. Professor,听Department of Medicine, 91社区 Tel: 514-934-1934 ext. 35833 andrew.bateman [at] mcgill.ca |
Biographical Sketch
Education
B.Sc. Imperial College of Science and Technology, University of London, (U.K.) Biochemistry 1981
Graduate Ph.D. Imperial College of Science and Technology, University of London, (U.K.) Biochemistry
Supervisor Professor, Anne Dell, 1985
Thesis topic: Fast Atom Bombardment Mass Spectrometry in the Study of Naturally Occurring Peptides
Post-graduate training
1985-1990 Postdoctoral Fellow, Endocrine Research Laboratory, Royal Victoria Hospital and 91社区 (Supervisor Professor Samuel Solomon)
Research project: Post-Translational Modification of Pituitary Peptides
University Appointments
1991-96 Assistant Professor, Medicine, 91社区, University
1996-2005 Associate Professor, Medicine, 91社区
2005 to present Full Professor, Medicine, 91社区
Keywords
Progranulin, neuroprotection, wound repair, growth factors, cell communication, cancer progression
Research or Clinical Activities
I study communication between cells and its relationship to disease. Progranulin is a protein that is secreted by cells and instructs nearby cells to divide and to move. It also inhibits cell death caused by challenges such as starvation or chemotherapeutic drugs and regulates lysosomal activity. There are many important roles for this molecule.
In animal models progranulin greatly slows, and even stops, the onset of neurodegenerative diseases, while in patients, heterozygous nonsense mutation of the progranulin gene causes frontotemporal dementia. I wish to understand how progranulin protects the brain and how this can be used to develop new neuroprotective therapies.
Progranulin reduces inflammation. Its levels increase rapidly in injured tissues. We have shown that progranulin helps wound repair and may have very useful activities for regenerative medicine. Progranulin is over expressed in many cancers and renders cancer cells more aggressive. Blocking progranulin may be a route to cancer therapy.
Selected Recent Publications
By: Chitramuthu Babykumari P, Campos-Garc铆a Victor R, Bateman Andrew.
FRONT. NEUROSCIENCE (2022) Volume 15: Article Number: 775391.
By: Doyle James J, Maios Claudia, Vrancx Celine, Duhaime Sarah, Chitramuthu Babykumari P, Bennett Hugh PJ, Bateman A, Parker JA.
Proc Natl Acad Sci U S A. (2021) Volume:118 Article Number: e2022115118.
By: Chitramuthu, Babykumari P.; Bennett, Hugh P. J.; Bateman, Andrew
BRAIN (2017) Volume: 140 Pages: 3081-3104
By: Palfree, Roger G. E.; Bennett, Hugh P. J.; Bateman, Andrew
PLOS ONE (2015) Volume: 10 Article Number: e0133749
By: Toh, Huishi; Cao, Mingju; Daniels, Eugene; Bateman Andrew.
PLOS ONE (2013) Volume: 8 Article Number: e64989