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Primary research interests include frailty, aging biology, risk prediction before cardiac surgery and TAVI, Cardiac MRI, Echocardiography, and the Right ventricle. Dr. Afilalo is the PI of the international 鈥淔RAILTY-AVR鈥� study comparing the impact of frailty assessment tools in elderly patients undergoing transcatheter and surgical aortic valve replacement. The translational arm of this research is dedicated to the discovery and validation of novel biomarkers for frailty. He is the PI of the 鈥淧OSSE鈥� registry (Pre-Operative Surgical Stratification using Echocardiography), which has yielded insights into the prognostic value of the echocardiogram in cardiac surgery patients. Dr. Afilalo was a co-author on the American Society of Echocardiography guidelines for right heart evaluation.