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My research is focused on developing interpretable probabilistic learning models and deep learning models to model genetic, epigenetic, electronic health record, and single-cell genomic data. By systematically integrating multimodal and longitudinal data, I aim to have impactful applications in computational medicine including building intelligent clinical recommender systems, forecasting patient health trajectories, personalized polygenic risk predictions, characterizing multi-trait functional genetic mutations, and dissecting cell-type-specific regulatory elements that are underpin complex traits and diseases in human. My research program covers three main research areas involving applied machine learning in (1) healthcare and public health, (2) computational genomics, and (3) population genetics.