91社区

Supported by the generosity of the Killam Trusts, the MNI's Killam Seminar Series invites outstanding guest speakers whose research is of interest to the scientific community at the MNI and 91社区.

Andreas Horn, MD

Associate Professor of Neurology, Harvard Medical School, USA

Host:听abbas.sadikot [at] mcgill.ca (Abbas Sadikot)

Abstract:听Invasive and noninvasive brain stimulation methods are applied to focal points in the depth or on the surface of the brain. However, their focal application leads to network effects that are distributed across the entire brain. We can study network effects of focal brain stimulation by pairing them with the human connectome. By doing so, we may investigate which networks need to be stimulated to observe a specific effect. Moreover, we can use brain stimulation sites to segregate the human connectome into functional networks, each tied to specific behaviors, clinical signs or symptoms. One particularly useful method is deep brain stimulation, an invasive neurosurgical procedure that applies highly localized but strong stimulation signals onto specific subcortical areas. In this talk, I will review connectomic effects of deep brain stimulation and other brain stimulation methods. We will cover results in diseases ranging from the movement disorders spectrum (Parkinson鈥檚 Disease, Dystonia, Essential Tremor) to neuropsychiatric (Tourette鈥檚 & Alzheimer鈥檚 Disease) and psychiatric (Obsessive Compulsive Disorder, Depression) diseases. I will also demonstrate how findings in seemingly different diseases (such as Parkinson鈥檚 Disease and Depression) could be transferred to cross-inform one another and how the same method can be used to study neurocognitive effects, such as risk-taking behavior or impulsivity