Killam Seminar Series: Schwann Cell Plasticity in Normal and Pathologic Human Peripheral Nerve
Supported by the generosity of the Killam Trusts, The Neuro's Killam Seminar Series invites outstanding guest speakers whose research is of interest to the scientific community at the MNI and 91社区.
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Alan Pestronk
Professor, Neurology and Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA
Host:听Jason Karamchandani
Abstract:听Peripheral nerve Schwann cells and myelin have varied molecular phenotypes, related to age, axon size and nerve pathology. In normal adult peripheral nerve, myelin has two different patterns of molecular composition. Myelin basic protein is mostly absent from myelin around a population of intermediate-sized axons, whereas P0 protein is present in myelin around all axons. Denervated Schwann cells have a molecular signature that differs from normal SC types. With acute axon loss, myelinating Schwann cells upregulate NCAM. Chronically denervated Schwann cells express both NCAM and P0. Studies of myelin and related cell composition in peripheral and central nervous system should provide insights into the pathogenesis and anatomical localization of nervous disease processes.
