Alyson Elise Fournier, PhD
La Pre Alyson Fournier s鈥檌nt茅resse aux m茅canismes cellulaires et mol茅culaires qui r茅gulent la d茅g茅n茅rescence et la r茅g茅n茅ration des axones. Les neurones du syst猫me nerveux central ne se r茅g茅n猫rent pas spontan茅ment 脿 la suite d鈥檜ne l茅sion traumatique ou sous l鈥檈ffet d鈥檜ne maladie neurod茅g茅n茅rative. L鈥檃bsence de r茅g茅n茅ration peut 锚tre attribu茅e 脿 l鈥櫭ヽhec des neurones l茅s茅s 脿 amorcer un programme de croissance et 脿 l鈥檈nvironnement inhibiteur de croissance. Les recherches de la Pre Fournier visent 脿 mieux comprendre la signalisation mol茅culaire dans les neurones 脿 la suite d鈥檜ne l茅sion traumatique ou de pouss茅es inflammatoires comme celles qui se produisent dans la scl茅rose en plaques. Les projets actuels portent sur le r么le des miARN et des prot茅ines adaptatrices 14-3-3 dans les r茅actions neuronales aux l茅sions. Une compr茅hension plus approfondie de ces r茅actions permettra de mettre au point des strat茅gies visant 脿 favoriser la neuroprotection et la r茅g茅n茅ration neuronale.
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Ong Tone S., Dayanandan B, Fournier, A.E*., Mandato, C.A.*. (2010) GSK3 Regulates Mitotic Chromosomal Alignment through CRMP4. PLoS ONE 5(12): e14345. * Co-corresponding authors.
Kent, C., Shimada, T., Ferraro, G., Rodriguez, S., Yam, P., Ritter, B., McPherson, P., Charron, F., Kennedy, T., Fournier, A.E. (2010) 14-3-3 proteins regulate growth cone responses through PKA. J. Neurosci. 30(42): 14059-14067
McKerracher, L., Fehlings, M., Fournier, A., Ong Tone, S. (2010 - In Press). Targeting Rho inactivation to promote regeneration and treat spinal cord injury: Bench to bedside translational medicine.. In: Essential of Spinal Cord Injury, Thieme Medical Publishers Inc. NY, NY.
Thomas, R., Favell, K., Morante-Redolat, J.M., Kent, K., Wright, M., Poole, M., Daignault, K., Fournier, A.E., P茅rez-Tur, J., Barker, P.A. (2010) LGI1 is a Novel Nogo Receptor Ligand that Blocks Myelin-based Growth Inhibition. Journal of Neuroscience: In press
Alabed, Y.Z., Pool, M., Ong Tone, S., Sutherland, C., Fournier, A.E. (2010) GSK3b regulates myelin dependent axon outgrowth inhibition through CRMP4. Journal of Neuroscience: In press
O'Connor, K.C., Lopez-Amaya, C., Gagne, D., Moore, N.H., Kennedy, J., Krupp, L., Tenembaum, S., Ness, J., Belman, A., Boiko, A., Bykova, O., Mah, J., Stoian, C., Waubant, E., Kremenchutzky, M., Ruggieri, M., Bardini, M.R., Rensel, M., Hahn, J., Weinstock-Guttman, B., Yeh, A., Farrell, K., Freedman, M., Livanainen, M., Bhan, V., Dilenge, M., Hancock, M.A., Gano, D., Fattahie, R., Kopel, L., Fournier, A.E., Hafler, D.A., Moscarello, M., Banwell, B., Bar-Or, A. (2010) Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis. J. Neuroimmunol., doi:10.1016/j.jneuroim.2010.02.019
Nash, M., Pribiag, H., Fournier, A.E., Jacobson, C. (2009) Central Nervous System Regeneration Inhibitors and their Intracellular Substrates. Mol. Neurobiology DOI 10.1007/s12035-009-8083-y
Pool, M., Niino, Rambaldi, I., Robson, K., Bar-Or, A., Fournier, A.E. (2009) Myelin regulates immune cell adhesion and motility. Exp. Neurol. 217(2):371-7
Moore, S.W., Correia, J.P., Lai Wing Sun, K., Pool, M., Fournier, A.E., Kennedy, T.E.. (2008) Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1. Development. 135(17):2855-64
Costantino, S., Kent, C.B., Godin, A.G., Kennedy, T.E., Wiseman, P.W., Fournier, A.E. (2008). Semi-Automated Quantification of filopodial dynamics. J. Neurosci. Methods 171(1): 165-173
Pool, M., Thiemann, J., Bar-Or, A., Fournier, A.E. (2008) NeuriteTracer: A novel ImageJ plugin for automated quantification of neurite outgrowth. J. Neurosci. Methods 168(1):134-139.
Alabed, Y.Z., Pool, M., OngTone, S., Fournier, A.E. (2007) Identification of CRMP4 as a convergent regulator of axon outgrowth inhibition. J. Neurosci. 27, 1702-1711.
Darenfed, H., Dayandana, B., Hsieh, S. H.-K., Fournier, A.E., Mandato. C.A. (2007) Molecular Characterization of the Effects of Y-27632. Cytoskeleton and Cell Motility. 64, 97-109.
Niino, M., Bodner, C., Simard, M.-L., Alatab, S., Gano, D., Kim, H., Trigueiro, M., Racicot, D., Gu茅rette, C., Mainville, M., Antel, J.P., Fournier, A.E., Grand聮Maison, F., Bar-Or, A. (2006) Natalizumab Effects on Immune Cell Responses in Multiple Sclerosis: The Expected and Less Expected. Ann. Neurol. 59:748聳754.
Alabed, Y.Z., Grados-Munro, E., Ferraro, G.B., Hsieh, S.H.-K., Fournier, A.E. (2006) Neuronal responses to myelin are mediated by ROCK. J. Neurochem. 96, 1616-1625
Hsieh, S. H.-K., Ferraro, G.B., Fournier, A.E. (2006) Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through Lim kinase and Slingshot phosphatase. J. Neurosci. 26(3), 1006-1015.
