Killam Seminar Series: Encoding Dopamine Signals in Striatal Circuits
Gr芒ce 脿 la g茅n茅rosit茅 des fiducies Killam, Le Neuro convoque lors d鈥檜ne s茅rie de s茅minaires des conf茅renciers d鈥檈xception dont les travaux passionnent ses chercheurs et ceux de l鈥橴niversit茅 91社区.听
Pour assister en personne,听
Pour regarder via Vimeo,听
Christopher Ford
Professeur, D茅partement de pharmacologie, Universit茅 du Colorado.
贬么迟别:听austen.milnerwood [at] mcgill.ca (Austen Milnerwood)
Abstract:听Ford's lab examines how neuromodulators are encoded in the mesolimbic and nigrostriatal systems and how circuit dysfunctions in these areas contribute to neurological and psychiatric disorders. Dopamine, acetylcholine and serotonin play key roles in the basal ganglia and nucleus accumbens, controlling a variety of motivated behaviors including decision-making, action selection, motor skill learning, habit formation and reward processing. The lab uses a combination of electrophysiology, 2-photon imaging, optogenetics, genetically encoded optical sensors, electrochemistry, in vivo fiber photometry and behavioral approaches to study how transmission mediated by these neuromodulators are encoded within mesolimbic and nigrostriatal circuits. By identifying the mechanisms regulating signaling Ford's lab aims to identify the disruptions in these systems that underlie psychiatric disorders such as drug addiction and schizophrenia and neurological disorders such as Parkinson鈥檚 disease.
