David Rudko, PhD
Professeur adjoint de neurologie, de neurochirurgie et de g茅nie biom茅dical 脿 l鈥橴niversit茅 91社区, David听Rudko est titulaire d鈥檜n doctorat en physique m茅dicale avec sp茅cialisation en imagerie par r茅sonance magn茅tique (IRM) 脿 ultra-haut champ de l鈥橴niversit茅 de Western Ontario. Les travaux r茅alis茅s dans son laboratoire portent principalement sur l鈥檃pplication de nouvelles m茅thodes d鈥橧RM concurremment avec la mod茅lisation biophysique pour mieux comprendre l鈥檃natomie et la physiologie du cerveau. 脌 titre de nouveau professeur adjoint au Centre d鈥檌magerie c茅r茅brale McConnell, David听Rudko a recours 脿 un appareil d鈥橧RM de haute puissance 脿 7听tesla pour 茅tudier les microstructures du tissu c茅r茅bral. 芦听Je m鈥檌nt茅resse aux alt茅rations de la structure du tissu c茅r茅bral en pr茅sence de maladies neurologiques听禄, explique le chercheur. 芦听Du point de vue clinique, mon laboratoire s鈥檌nt茅resse aux troubles d茅my茅linisants, comme la scl茅rose en plaques. Nous avons recours 脿 des mod猫les de maladies afin de d茅celer les maladies neurologiques 脿 un stade pr茅coce, de pr茅voir leur 茅volution et de tester l鈥檈fficacit茅 des traitements.听禄 Selon le Pr听Rudko, le regroupement sous un m锚me toit, au Neuro, de sp茅cialistes en recherche fondamentale et de cliniciens d鈥檈xception 芦听permet la r茅alisation des 茅tudes d茅terminantes dont nous avons besoin aujourd鈥檋ui au Canada pour faire progresser la recherche m茅dicale.听禄
1. Hosseini Z., Matusinec J.A., Rudko D.A., Liu J., Kwan B.Y.M., Salehi F., Sharma M., Kremenchutzky M., Menon R.S., Drangova M. "Morphology-Specific Discrimination Between MS White Matter Lesions and Benign White Matter Hyperintensities Using Ultra-High Field MRI," American Journal of Neuroradiology. Accepted, May 2018.
2.听Akbar N.A., Rudko D.A., Parmar K. "Magnetic resonance imaging of multiple sclerosis," Scientific Journal of Multiple Sclerosis. November 2017; 1(1):008-020.
3. Maranzano J., Rudko D.A., Arnold D.L., Narayanan S. "MRI evidence of acute inflammation in leukocortical lesions of early multiple sclerosis patients," Neurology. August 2017;听89(7):714-721.
4.听Bernhardt B.C., Fadaie F., Vos de Wael R., Hong S.J., Liu M., Guiot M.C., Rudko D.A., Bernasconi A., Bernasconi N. "Preferential susceptibility of limbic cortices to microstructural damage in temporal lobe epilepsy: A quantitative T1 mapping study," NeuroImage. June 2017; S1053-8119(17): 30471-8.
5.听Streijger F., Lee J.H.T., Manouchehri N., Anderson L., Okon E.B., Tigchelaar S., Anderson L.M., Dekaban G.A., Rudko D.A., Menon R.S., Iaci J.F., Button D.C., Vecchione A.M., Konovalov A., Sarmiere P.D., Ung C., Caggiano A.O., Kwon B.K. "The evaluation of magnesium chloride with a polyethyelene glycol formulation in a porcine model of acute spinal cord injury," Journal of Neurotrauma. December 2016; 33(24):2202-2216.
6.听Rudko D.A, Derakhshan M., Maranzano J., Nakamura K. Arnold D.L., Narayanan S. "Delineation of cortical pathology in multiple sclerosis using multi-surface magnetization transfer ratio imaging," NeuroImage: Clinical. October 2016; 73(4):1654-1661.
7. Maranzano J., Rudko D.A., Arnold D.L., Narayanan S. "Manual segmentation of MS cortical lesions using MRI: A comparison of three MRI reading protocols," American Journal of Neuroradiology. September 2016; 37(9):1623-1628.
8. Junmin Liu, Rudko D.A., Gati J.S., Menon R.S., Drangova M. "Inter-echo variance as a weighting factor for multi-channel combination in multi-echo acquisition for local frequency shift mapping," Magnetic Resonance in Medicine. April 2015; 73(4):1654-1661.
9. Rudko D.A., Solovey I., Gati J.S., Kremenchutzky M., Menon R.S. "Multiple Sclerosis: improved identification of MS disease-relevant changes in gray and white matter using susceptibility-based MR imaging," Radiology. September 2014; 272(3):851:864.
10. Goubran M., Rudko D.A., Santyr B., Gati J., Szekeres T., Peters T.M., Khan A.R. "In vivo normative atlas of the hippocampal subfields using multi-echo susceptibility imaging at 7 Tesla," Human Brain Mapping. Aug. 2014; 35(8):3588-3601.
11. Rudko D.A., Racosta J., Kremenchutzky M. "Monitoring increased iron levels in multiple sclerosis using MRI," Future Neurology. July 2014; 9(4): 387-391.
12. Rudko D.A., Klassen L.M., de Chickera S.N., Gati J.S., Dekaban G.A., Menon R.S. "Origins of R2*听orientation dependence in gray and white matter," Proceedings of the National Academy of Sciences of the United States of America. Jan 7, 2014;111(1):E159-67.
13. Campbell W.G., Rudko D.A., Braam N.A., Wells, D.M., Jirasek A. "A prototype fan-beam optical CT scanner for 3D dosimetry," Medical Physics. June 2013;40(6):061712.
