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UID:20250421T153637EDT-8125TewX7n@132.216.98.100
DTSTAMP:20250421T193637Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and 91ÉçÇř Univers
 ity.\n\n\nRegister Now\n\nTo watch online\, click here\n\n\nElsa Rossignol
 \n\nPersonalized Medicine and a Quest for Better Therapies to Treat CACNA1
 A-Related Epilepsy\n\nElsa Rossignol is a pediatric neurologist specialize
 d in neurogenetics\, with a focus on the genetic causes underlying neurode
 velopmental disorders such as epilepsy\, autism\, and intellectual deficie
 ncy. Her laboratory pursues two main lines of research to investigate thes
 e conditions. First\, her team examines the molecular basis of severe chil
 dhood epileptic disorders using whole-genome sequencing in cohorts of pati
 ents with various seizure disorders. In parallel\, they use genetic mouse 
 models of these disorders to explore how mutations in specific genes impac
 t neuronal development or function\, leading to epilepsy. Dr. Rossignol's 
 research is particularly focused on the development of GABAergic interneur
 ons—brain inhibitory neurons—and their role in regulating seizure generati
 on and cognitive functions. Her team employs targeted genetic ablation str
 ategies to selectively remove genes of interest in specific subtypes of in
 terneurons. The consequences of these manipulations are studied using a co
 mbination of in vivo EEG recordings\, in vitro physiological recordings\, 
 and immunohistochemical techniques. By integrating basic science and clini
 cal approaches\, Dr. Rossignol's research aims to illuminate the mechanism
 s underlying severe epileptic syndromes and potentially pave the way for n
 ew therapeutic strategies for affected patients.\n
DTSTART:20250121T210000Z
DTEND:20250121T220000Z
LOCATION:de Grandpre Communications Centre\, The Neuro
SUMMARY:Killam Seminar Series: Personalized Medicine and a Quest for Better
  Therapies to Treat CACNA1A-Related Epilepsy
URL:/neuro/channels/event/killam-seminar-series-person
 alized-medicine-and-quest-better-therapies-treat-cacna1a-related-362696
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