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DTSTAMP:20250421T193604Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and 91ÉçÇø Univers
 ity.\n\n\nRegister Now\n\nTo watch online\, click here\n\nHost: Amir Shmue
 l\n\n\nNew Frontiers in Imaging the Human Connectome\n\nAbstract: To this 
 day\, critical procedures in neurosurgery and neuromodulation for patients
  with devastating diseases are guided by knowledge on how the brain is wir
 ed that derives largely from animal studies. Such studies rely on the prec
 ision of techniques\, like tracer injections\, that are not feasible in hu
 man subjects. Inter-species homologies\, particularly between non-human pr
 imates and humans\, are then used to extrapolate information from the form
 er to the latter. This approach has afforded us an understanding of broad 
 organizational principles in the wiring of the human brain\, but crucial d
 etails are missing. Recent advances in ex vivo tissue processing and micro
 scopy show great promise for imaging the wiring of the human brain down to
  the scale of single axonal projections. Much work is needed\, however\, t
 o turn these breakthroughs into tools in the hands of anatomists. Doing so
  will allow us to map precisely\, for the first time\, clinically relevant
  brain circuits and to design better therapeutic interventions. It will al
 so provide the ground truth that we need to harness recent advances in art
 ificial intelligence and improve noninvasive imaging of the wiring of the 
 brain with diffusion MRI. In this talk\, Anastasia will present the center
  for Large-scale Imaging of Neural Circuits (LINC)\, a multi-institutional
  consortium funded by the NIH BRAIN Initiative to lay the technological gr
 oundwork for imaging the wiring of the human brain across scales\, from th
 e large highways to the small fascicles and down to the single axon level.
  Anastasia will discuss the image acquisition and analysis advances that w
 ill be needed to make this previously unattainable goal a reality.\n\nAnas
 tasia Yendiki\n\nAssociate Professor in Radiology\, Harvard Medical School
  and Massachusetts General Hospital\n\nAnastasia Yendiki is Associate Prof
 essor in Radiology at Harvard Medical School and Associate Investigator at
  Massachusetts General Hospital\, Martinos Center for Biomedical Imaging. 
 She is the lead PI of the center for Large-scale Imaging of Neural Circuit
 s (LINC)\, a multi-institutional consortium funded by the NIH BRAIN Initia
 tive CONNECTS program\, with the aim of imaging human and non-human primat
 e brain circuitry across scales. Anastasia received her Ph.D in Electrical
  Engineering: Systems from the University of Michigan at Ann Arbor\, where
  she worked on inverse problems in tomographic image reconstruction. She t
 hen moved to the Martinos Center\, first as a postdoc and then as a facult
 y member. There she developed TRACULA\, the diffusion tractography toolbox
  in the FreeSurfer software package. She has served as MGH site PI in the 
 Connectomes Related to Human Disease\, and spearheaded the IronTract Chall
 enge\, an initiative bringing together tractography developers from around
  the world to compare and optimize the accuracy of their methods using gol
 d standard post mortem data. Her current interests are in obtaining accura
 te models of white-matter fiber bundles from microscopy techniques\, such 
 as anatomic tracing and optical imaging\, and developing methods that can 
 take advantage of these post mortem models to infer connectional anatomy f
 rom in vivo diffusion MRI.\n
DTSTART:20250325T200000Z
DTEND:20250325T210000Z
LOCATION:de Grandpre Communications Centre\, The Neuro
SUMMARY:Killam Seminar Series: New Frontiers in Imaging the Human Connectom
 e
URL:/neuro/channels/event/killam-seminar-series-new-fr
 ontiers-imaging-human-connectome-364263
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