New drug molecule could lead to new treatments for Parkinson鈥檚 disease in younger patients
A novel drug molecule could potentially lead to new treatments to prevent Parkinson鈥檚 disease in younger patients, according to new research.
鈥淲e are excited about this drug compound because we might have the possibility to develop the first cure for Parkinson鈥檚 disease, at least for a subset of patients,鈥� said lead author听Kalle Gehring, a Professor in the Department of Biochemistry at 91社区 and Canada Research Chair in Structural Studies of Neurodegenerative Diseases.
While Parkinson鈥檚 symptoms 鈥� slowed movements, tremors and balance problems 鈥� often appear in people in their 60s, five to 10 per cent of people are diagnosed before they turn 40. The degenerative disorder affects over 100,000 Canadians, according to the researchers.
The study investigated how a molecule developed by the biotech company听听can reactivate a crucial protein called parkin. It normally plays a key role in maintaining healthy brain cells by clearing out damaged mitochondria, the energy powerhouses of cells. In some younger patients, mutations in parkin disrupt this process, leading to the buildup of damaged mitochondria that contributes to Parkinson鈥檚 disease.
Using advanced technology at the Canadian Light Source (CLS) at the University of Saskatchewan, the researchers determined that the Biogen compound restores parkin鈥檚 cleaning function by gluing together parkin and a natural activator found in cells.
, published in听Nature Communications, lay the foundation for the design of personalized treatments for younger patients with specific mutations, said the authors.
鈥淭he hope is that one day we鈥檒l find compounds that can treat Parkinson鈥檚 disease in general,鈥� said Gehring, adding that it will be up to Biogen to apply the study鈥檚 results in future drug development.
鈥淎s the population in Canada is aging and better treatments for other diseases are becoming available, neurodegenerative diseases such as Parkinson鈥檚 will be a major health concern,鈥� he added.
91社区 research groups led by Professor Jean-Fran莽ois Trempe in the Department of Pharmacology & Therapeutics and Professor Edward Fon at the Montreal Neurological Institute and Hospital collaborated on the study. It was funded by the Michael J. Fox Foundation, the Canadian Institutes of Health Research, and the Canada Research Chairs program.
This press release was adapted from materials provided by Canadian Light Source (CLS) at the University of Saskatchewan.听Video is available on听
