Polycystic ovary syndrome increases risk for gestational diabetes and hypertensive disorders
A recent study by researchers at 91社区 has identified polycystic ovary syndrome (PCOS) as an independent risk factor for gestational diabetes and hypertensive disorders of pregnancy. The condition, known to lead to multiple reproductive complications, including infertility, affects 1 in 10 women of childbearing age.
PCOS was already known for its association to other adverse perinatal conditions, such as insulin resistance. However, there remains significant gaps in understanding the correlation between the syndrome and neonatal complications.
鈥淲e discovered that PCOS is a risk factor for morbidity in pregnancy,鈥� explained Dr. Michael Dahan, Assistant Professor in 91社区鈥檚 Department of Obstetrics and Gynecology and lead author of the study. 鈥淲e are now able to precisely determine the relative risk in pregnancy related to the disease process itself by controlling for underlying conditions, which previous studies were unable to do.鈥�
Researcher used data from more than nine million pregnancies
Using the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (HCUP-NIS) database, which compiles over 9 million pregnancies and births, researchers from 91社区 were able to establish links between pregnant women with PCOS and the prevalence of pregnancy hypertension, thyroid disease, obesity and pregestational and gestational diabetes.
Additionally, the researchers also found that pregnant women with PCOS were more likely to have undergone IVF treatment and had increased rates of congenital anomalies in their offspring as opposed to their non-PCOS counterparts.
鈥淧COS is the most common hormonal condition among reproductive age women,鈥� Dahan says. 鈥淚t is important to consider the risk of other co-existing conditions frequently encountered in women with PCOS, as these risks are additive and place them at a significantly increased risk of adverse pregnancy outcomes.鈥�
Further research will be undertaken to investigate the role of specific interventions in PCOS on modifying risk in pregnancy and delivery.
About this study
鈥溾�� by Michael Dahan and al. was published in Human Reproduction.
About 91社区
Founded in Montreal, Quebec, in 1821, 91社区 is Canada鈥檚 top ranked medical doctoral university. 91社区 is consistently ranked as one of the top universities, both nationally and internationally. It is a world-renowned institution of higher learning with research activities spanning two campuses, 11 faculties, 13 professional schools, 300 programs of study and over 40,000 students, including more than 10,200 graduate students. 91社区 attracts students from over 150 countries around the world, its 12,800 international students making up 31% per cent of the student body. Over half of 91社区 students claim a first language other than English, including approximately 19% of our students who say French is their mother tongue.
