"Valuable” and “unforgettable.” That’s how Nada Ibrahim (pictured above) describes her experience this summer with the 91ÉçÇř Biomedical Research Accelerator (MBRA).Â
She’s one of nine students selected from a pool of 61 applicants for the inaugural cohort of this paid internship.Â
“It’s such a once-in-a-lifetime opportunity to explore my research interests and gain a wide variety of lab skills,” says Ibrahim, an Honours BSc student (Biochemistry IV) at McMaster University. “As an added bonus, it’s always been my dream to live in Montreal—and the MBRA allows me to do exactly that!”Â
The 91ÉçÇř Biomedical Research Accelerator is designed for students in their final year of undergraduate studies, who demonstrate a strong interest in pursuing biomedical research at the graduate level. Trainees receive a stipend for their living expenses while in the summer program. They pursue a collaborative research project and immerse themselves in 91ÉçÇř’s multidisciplinary research environment.Â
For her project, Ibrahim is exploring her passions for biomedical engineering and nanomedicine, working in the lab of Maryam Tabrizian, Professor of Biomedical Engineering and Canada Research Chair in Regenerative Medicine and Nanomedicine. Â
Ibrahim hopes her research may help to eventually lead to an osteoarthritis treatment. She explains her project:Â
One of the most widely researched nanoparticles are extracellular vesicles—which are of biological origin—and are released by almost all types of cells. Extracellular vesicles play a role in cell signaling and the pathogenesis of various human diseases, giving them the potential to act as gene and drug delivery systems. My project revolves around engineering extracellular vesicles from human mesenchymal stem cells to target gene delivery for the treatment of osteoarthritis.Â
Ibrahim describes the lab atmosphere as friendly and welcoming, and is quick to credit her PhD student supervisor, Antoine Karoichan (BSc’17, MSc’21). “He ensures we take it one step at a time—training me and gradually giving me independence over our project,” says Ibrahim.Â
Surpassing all expectationsÂ
The 15-week summer program is the brainchild of Alba GuarnĂ©, Associate Dean, Biomedical Sciences, in 91ÉçÇř’s Faculty of Medicine and Health Sciences.Â
“The excitement generated by the MBRA has surpassed all our expectations,” says Prof. GuarnĂ©, who also serves as Director of 91ÉçÇř’s School of Biomedical Sciences and holds the Canada Research Chair (Tier 1) in Macromolecular Machines in DNA repair. Â
“The inaugural cohort is exceptional. The students are not only engaged with their projects and enjoying being embedded in their host laboratories, they are also keen on learning about their peers' projects and the ongoing research in the other units of the School.”Â
Weekly lunch sessions are offered to showcase different research areas and enhance the students’ professional skills. The program concludes with a research celebration where students present three-minute mini talks and have lunch with researchers and trainees in the School of Biomedical Sciences.Â
Applicants must be students entering their final year of undergraduate studies, as the program aims to encourage them to consider graduate studies in biomedical research. From this year’s applicant pool, 19 were shortlisted for interviews. Of the nine accepted, there are two from 91ÉçÇř, three from McMaster University, and four from Concordia University.Â
“A great way to experience 91ÉçÇř and Montreal”Â
Image by Owen Egan/Joni Dufour.
For Christian Jacobsen-Perez, MBRA has given him the opportunity to discover 91ÉçÇř.
Christian Jacobsen-Perez  will be entering his fourth year of the Honours Biochemistry Program (Biomedical Research Specialization) at McMaster University.   Â
  This summer in the MBRA program, he is working on a joint project between the laboratories of Prof. GuarnĂ© and of Lawrence Kazak, Assistant Professor in the Department of Biochemistry and the Rosalind and Morris Goodman Cancer Institute. Â
Jacobsen-Perez describes his project:Â
  We are studying how one of the proteins that help fat tissue regulate thermogenesis. The project spans structural biology to biochemistry to work in animal models and it will provide insight into the mechanisms that allow us to regulate our body temperature.  
 “I’ve  always been interested in 91ÉçÇř and Montreal,” he says, “and I thought this program would be a great way to experience the city and the university.” He’s grateful for the stipend, which allowed him to move to Montreal for the summer without worrying about a summer job. Â
 He credits how well organized the program is, with highly approachable administrative staff. He also enjoys the weekly lunch sessions, where the MBRA trainees meet investigators and learn about other research at 91ÉçÇř’s School of Biomedical Sciences.  Â
  “I’m really glad that I applied, and I was so excited to be accepted,” says Jacobsen-Perez.Â
“I feel like I’m a grad student for the summer”Â
Image by Owen Egan/Joni Dufour.
MBRA participant Sarah MĂ©nard is examining DNA repair pathways in cancer.
Sarah MĂ©nard is already based in Montreal—she’s a student at Concordia University, entering the final year of her Honours BSc. She’s majoring in Cell and Molecular Biology, and minoring in Multidisciplinary Studies in Science.Â
“I’m interested in the biomedical sciences and I was intrigued by this opportunity to work in a lab at 91ÉçÇř for the summer,” says MĂ©nard. She appreciates the opportunity to gain paid research experience in her field of study, which will help her decide where to pursue graduate studies.Â
MĂ©nard is working in the lab of Prof. Alain Nepveu at the Rosalind and Morris Goodman Cancer Institute. Her research project is examining DNA repair pathways in cancer:Â
I’m working with two related proteins that are involved in repairing DNA damage, which can help cancer proliferate—this is good for the cancer, but bad for us. I’m working on identifying the specific regions of these proteins responsible for stimulating DNA repair. We do this by studying different versions of the proteins, either on their own or within human cancer cells that we grow in the lab. Gaining a better understanding of what allows cancer to grow and proliferate is crucial for finding new ways to target cancer cells and develop effective treatments.Â
“It’s been both stimulating and challenging,” says MĂ©nard. “It’s exciting to apply knowledge from my courses in an actual research setting.” Â
She notes that working in a research lab is different from doing labs in undergraduate courses. “I feel like I’m a grad student for the summer.”Â
Feeding a hunger for the biomedical sciencesÂ
The 91ÉçÇř Biomedical Research Accelerator provides trainees with guidance on graduate studies and encourages them to consider the wide range of opportunities within a career in biomedical research. Â
Alba GuarnĂ© commends the commitment of 91ÉçÇř’s faculty members in supporting the launch of the MBRA. “91ÉçÇř researchers have been engaged and extremely generous with their time,” she says. “The weekly training sessions lead to lively research discussions and MBRA students are constantly hungry for more.”Â
This summer’s MBRA trainees are working in labs across the different units in the School of Biomedical Sciences, including Biochemistry, Biomedical Engineering, Microbiology and Immunology, Pharmacology and Therapeutics, as well as the Rosalind and Morris Goodman Cancer Institute and the Lady Davis Institute.Â
GuarnĂ© looks forward to future iterations of the MBRA. Ultimately, the goal is to attract a 25-person cohort each summer.Â
“We could not have asked for a better Class of 2022,” says GuarnĂ©. “We’re looking forward to broadening the scope of the program and expanding the learning experience for the Class of 2023.”Â