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John Hanrahan

Academic title(s): 

Professor, Department of Physiology

John Hanrahan
Contact Information
Address: 

Department of Physiology
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McIntyre Medical Sciences Building,
Room 1013
3655 Promenade Sir William Osler
Montr茅al, Qu茅bec H3G 1Y6

Email address: 
john.hanrahan [at] mcgill.ca
Phone: 
(514) 398-8320 (office)
(514) 398-4323 (laboratory)
Department: 
Physiology
Area(s): 
Cell and Molecular Biology
Degree(s): 

BSc(Hon), Dalhousie; PhD, UBC; Postdoc, Yale听

Current research: 

Our main goal is to understand epithelial chloride transport at the molecular level.听 Most of our effort focuses on CFTR (cystic fibrosis transmembrane conductance regulator), a low-conductance channel which mediates cAMP-stimulated chloride and bicarbonate secretion and is defective in the disease cystic fibrosis.听 We use site-directed mutagenesis, electrophysiological and imaging methods to study the structure and function of CFTR in heterologous expression systems, cell lines, and primary epithelial cell cultures.听 A recent emphasis has been the development of F508del-CFTR correctors for the treatment of CF. Other projects investigate the role of CFTR in mucus production and in chronic obstructive pulmonary disease.听

Link(s): 
Selected publications: 

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