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Pain and Neuroscience

Dr. Meloto鈥檚 research program is focused on filling in the major gap that exists in the scientific evidence needed to support clinical practice that recognizes distinct clinical clusters of patients based on targeting their molecular pathways of vulnerability. Such recognition needs to be taken into account both for treatment and prevention of pain chronification. Currently, Dr. Meloto is working on projects testing treatment options targeting specific neurobiological mechanisms with the goal of determining the subgroups of patients that will benefit from these treatments; developing a platform for the continuous enrolment of patients with acute low back pain (LBP), temporomandibular disorder (TMD), and post-operative pain, with the goal of finding treatment options that prevent pain from becoming chronic; and also investigating how genetic and biopsychological factors that predispose to TMD apply to the use of temporomandibular joint implants, with the goal of optimizing the selection criteria for TMJ implant patients.